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KMID : 0043320110340060869
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Archives of Pharmacal Research
2011 Volume.34 No. 6 p.869 ~ p.873
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Triterpenoid saponins from the seeds of Caragana microphylla
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Jin Gui Lin
Zheng Cheng Jian
Xin Wen Bo
Mao Zhu Jun
Sun Pei Xin
Zeng Zhi Xin
Qin Lu Ping
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Abstract
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Two new triterpenoid saponins, namely caraganoside C (1) and caraganoside D (2), were isolated from the seeds of Caragana microphylla. Their structures were elucidated on the basis of spectroscopic analyses, including homo- and hetero-nuclear correlation NMR experiments (COSY, HSQC and HMBC). Both 1 and 2 exhibited moderate inhibitory activity against NO production in LPS-stimulated RAW264.7 cells with IC50 values of 26.4 μM and 32.2 μM, respectively. In addition, 1 showed weak cytotoxicity against MCF-7, HL-60, HCT116, and A549 cell lines.
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KEYWORD
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Caragana microphylla, Triterpenoid saponin, Nitric oxide production inhibitor, Cytotoxicity
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